Nathan D M
Diabetes Care. 1982 Mar-Apr;5(2):105-10. doi: 10.2337/diacare.5.2.105.
Brittle, insulin-dependent diabetic patients with extremely labile glucose control requiring frequent hospitalizations were treated with a continuous subcutaneous insulin infusion delivered with a programmable pump. As reported by others, the patients did not improve with a regimen of preprandial boluses superimposed on a continuous single-rate infusion. However, they demonstrated dramatic clinical and metabolic improvement with a modified pump regimen that delivered a variable square-wave insulin infusion and avoided any boluses. These very difficult patients can benefit by insulin pump therapy.
脆性、胰岛素依赖型糖尿病患者，血糖控制极不稳定，需要频繁住院，采用可编程泵进行持续皮下胰岛素输注治疗。正如其他人所报道的，在持续单速率输注基础上追加餐前大剂量胰岛素的治疗方案，患者病情并未改善。然而，采用一种改良的泵治疗方案，即进行可变方波胰岛素输注且避免任何大剂量注射，患者在临床和代谢方面都有显著改善。这些病情非常棘手的患者可从胰岛素泵治疗中获益。
