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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Evered D F, Vadgama J V

Br J Nutr. 1983 Jan;49(1):35-42. doi: 10.1079/bjn19830008.

Transport of L-homocitrulline, an amino acid which occurs in milk products, was studied with rat small intestine in vitro and from the human mouth in vivo. Absorption was partially dependent, in both systems, on the presence of sodium ions. 2. Metabolic inhibitors decreased L-homocitrulline uptake across the small intestine. Transport across the intestine did not occur against the concentration gradient but did show saturation kinetics. 3. The barbiturate, amytal, did not inhibit buccal absorption. Saturation kinetics were demonstrated. 4. Experiments were conducted with L-citrulline, or other amino acids, as possible inhibitors of L-homocitrulline transport. Results were compatible with Na+-dependent carrier-mediated uptake across the buccal mucosa. Active transport could be involved with the small intestine assuming that L-homocitrulline has a low affinity for the carrier system.

以大鼠小肠进行体外研究，并从人体口腔进行体内研究，对乳制品中存在的一种氨基酸——L-高精氨酸的转运进行了研究。在这两种系统中，吸收部分依赖于钠离子的存在。2. 代谢抑制剂降低了L-高精氨酸在小肠中的摄取。跨肠转运并非逆浓度梯度发生，但确实表现出饱和动力学。3. 巴比妥酸盐戊巴比妥不抑制口腔吸收。呈现出饱和动力学。4. 用L-瓜氨酸或其他氨基酸作为L-高精氨酸转运的可能抑制剂进行了实验。结果与通过颊黏膜的钠离子依赖性载体介导摄取相符。假设L-高精氨酸对载体系统的亲和力较低，主动转运可能与小肠有关。

Evered D F, Vadgama J V

Br J Nutr. 1983 Jan;49(1):35-42. doi: 10.1079/bjn19830008.

Transport of L-homocitrulline, an amino acid which occurs in milk products, was studied with rat small intestine in vitro and from the human mouth in vivo. Absorption was partially dependent, in both systems, on the presence of sodium ions. 2. Metabolic inhibitors decreased L-homocitrulline uptake across the small intestine. Transport across the intestine did not occur against the concentration gradient but did show saturation kinetics. 3. The barbiturate, amytal, did not inhibit buccal absorption. Saturation kinetics were demonstrated. 4. Experiments were conducted with L-citrulline, or other amino acids, as possible inhibitors of L-homocitrulline transport. Results were compatible with Na+-dependent carrier-mediated uptake across the buccal mucosa. Active transport could be involved with the small intestine assuming that L-homocitrulline has a low affinity for the carrier system.

以大鼠小肠进行体外研究，并从人体口腔进行体内研究，对乳制品中存在的一种氨基酸——L-高精氨酸的转运进行了研究。在这两种系统中，吸收部分依赖于钠离子的存在。2. 代谢抑制剂降低了L-高精氨酸在小肠中的摄取。跨肠转运并非逆浓度梯度发生，但确实表现出饱和动力学。3. 巴比妥酸盐戊巴比妥不抑制口腔吸收。呈现出饱和动力学。4. 用L-瓜氨酸或其他氨基酸作为L-高精氨酸转运的可能抑制剂进行了实验。结果与通过颊黏膜的钠离子依赖性载体介导摄取相符。假设L-高精氨酸对载体系统的亲和力较低，主动转运可能与小肠有关。