Dosoretz D E, Murphy G F, Raymond A K, Doppke K P, Schiller A L, Wang C C, Suit H D
Cancer. 1983 Jan 1;51(1):44-6. doi: 10.1002/1097-0142(19830101)51:1<44::aid-cncr2820510111>3.0.co;2-d.
The records of 30 patients with primary lymphoma of bone (PLB) who were treated with radiation therapy were reviewed. The probability of NED-survival and overall survival at five-year follow-up was 53 and 63%, respectively. There were three local failures following treatment. The cumulative incidence of local recurrence was 14% at five years. No local failures were observed when tumors received doses higher than 50 Gy, or equivalent to a TDF of 70 or greater. The number of failures was too small to examine for a correlation between histologic subclassification and local control frequency if doses higher than 50 Gy were utilized. Complications of treatment occurred in four patients. Functional results were excellent in all except two patients. These data provide guidelines for determination of a clinically appropriate radiation dose level for PLB.
回顾了30例接受放射治疗的原发性骨淋巴瘤（PLB）患者的记录。五年随访时无疾病证据生存和总生存的概率分别为53%和63%。治疗后有3例局部失败。五年时局部复发的累积发生率为14%。当肿瘤接受高于50 Gy的剂量或等效TDF为70或更高时，未观察到局部失败。如果使用高于50 Gy的剂量，失败病例数太少，无法检验组织学亚分类与局部控制频率之间的相关性。4例患者出现治疗并发症。除2例患者外，所有患者的功能结果均极佳。这些数据为确定PLB临床适宜的放射剂量水平提供了指导。
