Leong B K, Kociba R J, Pernell H C, Lisowe R W, Rampy L W
J Toxicol Environ Health. 1978 Jul;4(4):645-59. doi: 10.1080/15287397809529687.
Rats and hamsters were exposed to the dust of pulverized asbestos pipe covering at an average concentration of 85 mg/m(3) for 6 h/d, 5 d/wk, for 7 mo, followed by a lifetime observation period. In rats, the pulmonary responses were alveolar adenomatous proliferation, nonprogressive fibrosis, squamous metaplasia, and a substantial incidence of pulmonary carcinoma formation. A smaller group of hamsters exposed under these conditions experienced an earlier onset of mortality than control hamsters, which were not subjected to the exposure regimen. Although this prevented conclusive evaluation of the pulmonary response in this species, no pulmonary neoplasms were noted in the surviving hamsters.
将大鼠和仓鼠暴露于平均浓度为85毫克/立方米的粉状石棉管覆盖物粉尘中，每天暴露6小时，每周暴露5天，持续7个月，随后进行终身观察期。在大鼠中，肺部反应为肺泡腺瘤样增生、非进行性纤维化、鳞状化生以及相当高的肺癌发生率。在这些条件下暴露的一小群仓鼠比未接受暴露方案的对照仓鼠更早出现死亡。尽管这妨碍了对该物种肺部反应的确定性评估，但在存活的仓鼠中未发现肺部肿瘤。
