Glasscock G F, Nicoll C S
Endocrinology. 1983 Mar;112(3):800-5. doi: 10.1210/endo-112-3-800.
Experiments were conducted to obtain information on the possible transfer of TSH and thyroid hormones from mother rats to their infants via milk. The mothers were thyroidectomized by surgical or chemical (tapazole) means to eliminate maternal thyroid hormones from milk while increasing its content of TSH. Their pups were either hypophysectomized (HX) or sham HX, and some pups were also chemically thyroidectomized (CTX) by tapazole injections. Surgical thyroidectomy (STX) of the mothers reduced the weight gain of HX and sham HX pups by 28% and 22%, respectively, but it did not affect tail growth in either group of pups, Their pups were either hypophysectomized (HX) or sham HX, and some pups were also chemically thyroidectomized (CTX) by tapazole injections. Surgical thyroidectomy (STX) of the mothers reduced the weight gain of HX and sham HX pups by 28% and 22%, respectively, but it did not affect tail growth in either group of pups, Their pups were either hypophysectomized (HX) or sham HX, and some pups were also chemically thyroidectomized (CTX) by tapazole injections. Surgical thyroidectomy (STX) of the mothers reduced the weight gain of HX and sham HX pups by 28% and 22%, respectively, but it did not affect tail growth in either group of pups, and it did not affect serum T4 levels in the sham HX infants. In contrast, CTX caused a pronounced inhibition of weight gain (-45%), tail growth (-45%), and serum T4 (to less than 0.5 micrograms/100 ml) in the sham HX pups. In comparison to the HX pups with euthyroid or STX mothers, the HX infants with CTX mothers also showed reduced weight gain (-57% and -40%, respectively) and tail growth (-40% and -34%, respectively). Tapazole injections into sham HX pups suckling CTX mothers further reduced weight gain, but not tail growth. Because skeletal growth in the pups is highly dependent on their thyroid status, the lack of effect of surgical TX of mothers on tail growth in their sham HX infants provides no evidence for the transfer of physiologically effective amounts of thyroid hormones from mother to infant via milk. Likewise, the failure of TX of mothers to affect the tail growth of the HX pups argues against milk TSH being of significance to the infant. However, the data obtained with the tapazole-treated mothers indicate that significant quantities of the drug are passed from mother to infant via milk.
进行了实验以获取有关促甲状腺激素（TSH）和甲状腺激素是否可能通过乳汁从母鼠转移至幼鼠的信息。通过手术或化学（他巴唑）方法切除母鼠的甲状腺，以消除乳汁中的母体甲状腺激素，同时增加其TSH含量。它们的幼崽要么接受垂体切除（HX），要么进行假垂体切除，并且一些幼崽还通过注射他巴唑进行化学甲状腺切除（CTX）。母鼠的手术甲状腺切除（STX）分别使HX和假HX幼崽的体重增加减少了28%和22%，但不影响两组幼崽的尾巴生长。它们的幼崽要么接受垂体切除（HX），要么进行假垂体切除，并且一些幼崽还通过注射他巴唑进行化学甲状腺切除（CTX）。母鼠的手术甲状腺切除（STX）分别使HX和假HX幼崽的体重增加减少了28%和22%，但不影响两组幼崽的尾巴生长。它们的幼崽要么接受垂体切除（HX），要么进行假垂体切除，并且一些幼崽还通过注射他巴唑进行化学甲状腺切除（CTX）。母鼠的手术甲状腺切除（STX）分别使HX和假HX幼崽的体重增加减少了28%和22%，但不影响两组幼崽的尾巴生长，且不影响假HX幼崽的血清T4水平。相比之下，CTX导致假HX幼崽的体重增加（-45%）、尾巴生长（-45%）和血清T4（降至低于0.5微克/100毫升）受到明显抑制。与具有甲状腺功能正常或STX母鼠的HX幼崽相比，具有CTX母鼠的HX幼崽的体重增加（分别为-57%和-40%）和尾巴生长（分别为-40%和-34%）也有所减少。对吸吮CTX母鼠乳汁的假HX幼崽注射他巴唑进一步降低了体重增加，但不影响尾巴生长。由于幼崽的骨骼生长高度依赖于其甲状腺状态，母鼠进行手术甲状腺切除对其假HX幼崽尾巴生长没有影响，这没有提供证据表明生理有效量的甲状腺激素通过乳汁从母体转移至幼崽。同样，母鼠甲状腺切除未能影响HX幼崽的尾巴生长，这也反驳了乳汁中的TSH对幼崽具有重要意义的观点。然而，用他巴唑处理母鼠所获得的数据表明，大量该药物通过乳汁从母体传递至幼崽。
