Gynning I, Johnsson J E, Alm P, Tropé C
Gynecol Oncol. 1983 Feb;15(1):18-26. doi: 10.1016/0090-8258(83)90112-9.
Two materials consisting of patients with early invasive squamous cell carcinoma of the uterine cervix have been studied in regard to the influence of age and treatment technique on prognosis. In the first material, consisting of 254 Stage Ib patients treated only with radiation therapy, a poorer prognosis was found in the women under 35 years of age. The second material consisted of 274 Stage Ib patients who had been preoperatively irradiated and had undergone radical hysterectomy. The prognosis was (not significantly) better for those patients under 35 years of age in this group. The rate of central recurrence was higher among the younger patients who received only radiation therapy. Analysis of histologic grading and cell type according to J. W. Reagan and S. F. Yao (Int. J. Radiat. Oncol. Biol. Phys. 5, 1015-1020 (1979) ) revealed no explanation for the poorer prognosis among younger women treated solely with radiation therapy.
针对年龄和治疗技术对预后的影响，对两组早期浸润性子宫颈鳞状细胞癌患者的资料进行了研究。第一组资料包括254例仅接受放射治疗的Ib期患者，发现35岁以下女性的预后较差。第二组资料包括274例术前接受过放射治疗并接受了根治性子宫切除术的Ib期患者。在这组中，35岁以下患者的预后（无显著差异）较好。仅接受放射治疗的年轻患者中央复发率较高。根据J.W.里根和S.F.姚（《国际放射肿瘤学、生物学、物理学杂志》5, 1015 - 1020 (1979)）的方法对组织学分级和细胞类型进行分析，未能解释仅接受放射治疗的年轻女性预后较差的原因。
