Toh S H, Claunch B C, Brown P H
J Clin Endocrinol Metab. 1983 Feb;56(2):405-9. doi: 10.1210/jcem-56-2-405.
Numerous studies have been done to determine the effects of long term calcitonin (CT) treatment on Paget's disease of bone, but very few studies have been undertaken to determine the long term CT effect on nonpagetic bone in man. Because of conflicting results of the CT effect on osteoporosis and also for further understanding of the role of CT on normal bone, we conducted a longitudinal prospective study on the effect of CT treatment on nonpagetic bone in patients with Paget's disease using monoenergetic photon absorptionmetry method. Patients with Paget's disease were given salmon CT daily for a period of 3 yr, the bone mineral content (BMC) in the nonpagetic distal radius was measured periodically for 3 yr, and the data were compared with those of the control group of patients with Paget's disease not receiving CT treatment. It was found that the control group showed a persistent gradual decrease in BMC during the study period of 3 yr, but the CT-treated group showed no decrease in BMC during the 3-yr period of treatment. Our study suggests that CT treatment may delay the natural course of bone demineralization with aging in patients with Paget's disease.
已经进行了大量研究以确定长期降钙素（CT）治疗对骨Paget病的影响，但很少有研究致力于确定CT对人体非Paget骨的长期影响。由于CT对骨质疏松症的影响结果相互矛盾，并且为了进一步了解CT在正常骨中的作用，我们使用单能光子吸收测定法对骨Paget病患者进行了一项关于CT治疗对非Paget骨影响的纵向前瞻性研究。给予骨Paget病患者每日鲑鱼降钙素，持续3年，在3年内定期测量非Paget桡骨远端的骨矿物质含量（BMC），并将数据与未接受CT治疗的骨Paget病对照组患者的数据进行比较。结果发现，对照组在3年的研究期间BMC持续逐渐下降，但CT治疗组在3年治疗期间BMC没有下降。我们的研究表明，CT治疗可能会延缓骨Paget病患者随着年龄增长而发生的骨质脱矿自然进程。
