慢性肾衰竭男性和女性患者高甘油三酯血症的不同病因？

Different causes for hypertriglyceridemia in male and female patients with chronic renal failure?

作者信息

Verschoor L, Baggen R G, Jansen H, Birkenhäger J C

出版信息

J Clin Endocrinol Metab. 1983 Mar;56(3):592-4. doi: 10.1210/jcem-56-3-592.

Abstract

The changes in plasma postheparin lipolytic activities that occur in patients with chronic renal insufficiency were found to be sex dependent. Male patients showed decreased hepatic lipase activity, while female patients exhibited decreased lipoprotein lipase activity. These findings offer 1) an explanation for the hitherto confusing data on postheparin lipolytic activities in chronic renal failure reported in the literature, and 2) a further argument for a role of hepatic lipase activity in the regulation of the breakdown of plasma triglycerides.

摘要

研究发现，慢性肾功能不全患者血浆肝素后脂解活性的变化存在性别差异。男性患者肝脂酶活性降低，而女性患者脂蛋白脂酶活性降低。这些发现为1）文献中报道的慢性肾衰竭患者肝素后脂解活性方面迄今令人困惑的数据提供了解释，以及2）肝脂酶活性在血浆甘油三酯分解调节中的作用提供了进一步的论据。