Kendrick K M
J Endocrinol. 1983 Jan;96(1):35-42. doi: 10.1677/joe.0.0960035.
Castration in the rat significantly lengthened the refractory period of medial preoptic-anterior hypothalamic neurones with outputs into the medial forebrain bundle but not of those with outputs to the lateral septum. Treatment with testosterone propionate reduced the neuronal refractory period to its lowest level at the same time as it restored mounts and intromissions (after 5 days). Equally, when treatment was ended at 15 days, mounts and intromissions were no longer shown when the refractory period lengthened again 14 days later. The sub-population of neurones which also received inputs from the contralateral fimbria (through the corticomedial amygdala) showed the same results as the overall population. Castration also significantly increased the baseline firing rates of medial preoptic-anterior hypothalamic neurones receiving inputs from the medial forebrain bundle. The same effect was observed for the sub-population of neurones which also had inputs from the contralateral fimbria, but castration significantly reduced the percentage of neurones responding to this additional input. The neurones having inputs with the fastest conduction velocity were responsible for these changes in firing rate and the input neurones were therefore probably non-dopaminergic.
对大鼠进行阉割显著延长了内侧视前区-下丘脑前部神经元的不应期，这些神经元的传出纤维投射到内侧前脑束，但投射到外侧隔的神经元的不应期未受影响。丙酸睾酮治疗在恢复爬跨和插入行为的同时（5天后）将神经元不应期缩短至最低水平。同样，当在15天时停止治疗，14天后不应期再次延长时，爬跨和插入行为不再出现。同样接受来自对侧穹窿（通过皮质内侧杏仁核）输入的神经元亚群与总体结果相同。阉割还显著提高了接受内侧前脑束输入的内侧视前区-下丘脑前部神经元的基础放电率。对于同样接受来自对侧穹窿输入的神经元亚群也观察到了相同的效应，但阉割显著降低了对这一额外输入产生反应的神经元百分比。具有最快传导速度输入的神经元导致了放电率的这些变化，因此输入神经元可能不是多巴胺能的。
