Smith J T, Acuff R V, Bittle J B, Gilbert M L
J Nutr. 1983 Feb;113(2):222-7. doi: 10.1093/jn/113.2.222.
Adult male Long-Evans rats (250-300 g) were fed diets containing 15% of casein not supplemented with amino acids, supplemented with 0.505% cysteine or supplemented with 0.620% methionine for a period of 17 days. Rats fed the diets supplemented with cysteine had an increased incorporation of the 14C-radioactivity from [U-14C]alanine into liver glycogen and a decreased incorporation from [U-14C]acetate into fatty acids. Pyruvate carboxylase activity was slightly increased and citrate cleavage enzyme activity decreased in the livers of those rats fed the diets supplemented with cysteine. Rats fed diets supplemented with methionine had a decreased liver phosphoenolpyruvate carboxykinase activity. Based on these data it appears that rats fed diets supplemented with cysteine adapt metabolically to store energy as glycogen, while those fed diets supplemented with methionine tend to store energy as lipid.
成年雄性Long-Evans大鼠（250 - 300克）被喂食含有15%酪蛋白且未添加氨基酸、添加0.505%半胱氨酸或添加0.620%蛋氨酸的日粮，持续17天。喂食添加半胱氨酸日粮的大鼠，[U-¹⁴C]丙氨酸的¹⁴C放射性掺入肝糖原增加，而[U-¹⁴C]乙酸盐掺入脂肪酸减少。喂食添加半胱氨酸日粮的大鼠肝脏中，丙酮酸羧化酶活性略有增加，柠檬酸裂解酶活性降低。喂食添加蛋氨酸日粮的大鼠肝脏磷酸烯醇丙酮酸羧激酶活性降低。基于这些数据，似乎喂食添加半胱氨酸日粮的大鼠在代谢上适应以糖原形式储存能量，而喂食添加蛋氨酸日粮的大鼠倾向于以脂质形式储存能量。
