Carlsson G, Hafström L, Hugander A, Jönsson P E, Bolmsjö M, Persson B
J Surg Oncol. 1983 Jan;22(1):37-40. doi: 10.1002/jso.2930220110.
The effect of general microwave hyperthermia and hepatic artery ligation (HAL) was tested on Wistar rats with a transplanted N-methyl-N-nitrosoguanidine-induced adenocarcinoma in the liver. Total body hyperthermia (41.5 degrees C for 1 hour, three times during 24 hours) was given on the same day as HAL, and 1, 2, and 3 days after. HAL induced a slower tumor growth than untreated controls. No additive effect was registered when total body microwave hyperthermia was added to HAL. When hyperthermia was added 2 days after HAL, there was a transient decrease in tumor volume as in the HAL series. Total body microwave hyperthermia added 3 days after HAL induced a faster tumor growth than after HAL alone. When hyperthermia was added the same day and 1 day after HAL, there was a 50% mortality.
在移植了经N-甲基-N-亚硝基胍诱导的肝癌的Wistar大鼠身上，测试了全身微波热疗和肝动脉结扎（HAL）的效果。全身热疗（41.5摄氏度，持续1小时，在24小时内进行3次）在HAL当天以及之后的第1、2和3天进行。与未治疗的对照组相比，HAL诱导肿瘤生长更缓慢。当全身微波热疗与HAL联合使用时，未观察到相加效应。当在HAL后2天进行热疗时，肿瘤体积出现短暂减小，与HAL组情况相同。在HAL后3天进行全身微波热疗，诱导肿瘤生长比单独HAL后更快。当在HAL当天和之后1天进行热疗时，死亡率为50%。
