Slutsky R A, Mancini G B, Gerber K H, Dittrich H C, Higgins C B
Am J Cardiol. 1983 Feb;51(3):468-75. doi: 10.1016/s0002-9149(83)80082-4.
Using equilibrium radionuclide angiography, an evaluation was made of the response of left ventricular ejection and filling rates at rest and during acute increases in afterload in 8 normal volunteer subjects and 10 patients with previous transmural myocardial infarctions. Using the postatropine point for comparison, normal patients increased ejection time and decreased peak ejection rate (-3.90 +/- 0.49 vol/s to -3.41 +/- 0.95 vol/s) and peak filling rate (3.94 +/- 0.88 vol/s to 3.51 +/- 0.38 vol/s). Infarct patients had similar responses, although all indexes were lower than the corresponding values in the normal subjects. At rest, the ratio of peak filling to emptying rate was similar in the normal subjects and the infarct patients (1.01 +/- 0.24 versus 0.99 +/- 0.25, respectively) and maintained that relationship after atropine (0.91 +/- 0.11 versus 0.81 +/- 0.21) and at the peak increase in arterial pressure (1.07 +/- 0.21 versus 1.02 +/- 0.32). The ratio of time to peak filling/time to peak emptying behaved in similar fashion regardless of the differences in the absolute values. In this study, left ventricular filling and emptying behaved in a similar fashion in response to the alteration in arterial pressure in normal subjects and in patients with previous myocardial infarctions.
利用平衡放射性核素血管造影术，对8名正常志愿者和10名曾有透壁性心肌梗死的患者在静息状态及后负荷急性增加时左心室射血和充盈率的反应进行了评估。以阿托品化后的点作为对照，正常患者的射血时间延长，射血峰值率降低（从-3.90±0.49毫升/秒降至-3.41±0.95毫升/秒），充盈峰值率降低（从3.94±0.88毫升/秒降至3.51±0.38毫升/秒）。梗死患者有类似反应，尽管所有指标均低于正常受试者的相应值。静息时，正常受试者和梗死患者的充盈峰值与排空率之比相似（分别为1.01±0.24和0.99±0.25），阿托品化后（0.91±0.11和0.81±0.21）以及动脉压峰值增加时（1.07±0.21和1.02±0.32）仍保持该关系。无论绝对值存在差异，达到充盈峰值的时间与达到排空峰值的时间之比的表现类似。在本研究中，正常受试者和曾有心肌梗死的患者的左心室充盈和排空对动脉压变化的反应方式相似。
