Alvarez O M, Mertz P M, Eaglstein W H
Arch Dermatol. 1983 Mar;119(3):222-5.
The effectiveness of 10%, 20%, and 50% benzoyl peroxide in a lotion, 20% benzoyl peroxide in a gel, and the effect of the vehicles alone on wound reepithelialization were evaluated in young domestic pigs. Twenty percent benzoyl peroxide suspension in a lotion base substantially increased the rate of reepithelialization by 33% over a seven-day evaluation period. Twenty percent benzoyl peroxide suspension in a gel base and 10% benzoyl peroxide suspension in a lotion base slightly enhanced epidermal resurfacing, while 50% benzoyl peroxide suspension in a lotion base and the vehicle gel retarded healing. Variations in the rate of reepithelialization were observed when different lots of 20% benzoyl peroxide lotions were compared. Chemical analysis of each of the 20% benzoyl peroxide preparations tested disclosed great differences in zinc, magnesium, and sodium content.
在幼年家猪身上评估了乳液状10%、20%和50%的过氧化苯甲酰、凝胶状20%的过氧化苯甲酰以及单纯载体对伤口再上皮化的效果。在为期七天的评估期内，乳液基质中20%的过氧化苯甲酰悬浮液使再上皮化速率大幅提高了33%。凝胶基质中20%的过氧化苯甲酰悬浮液和乳液基质中10%的过氧化苯甲酰悬浮液略微促进了表皮再形成，而乳液基质中50%的过氧化苯甲酰悬浮液和载体凝胶则延缓了愈合。比较不同批次的20%过氧化苯甲酰乳液时，观察到再上皮化速率存在差异。对所测试的每种20%过氧化苯甲酰制剂进行化学分析发现，锌、镁和钠含量存在很大差异。
