Hebert J C, Gamelli R L, Foster R S, Chalmer B J, Davis J H
Arch Surg. 1983 Mar;118(3):328-32. doi: 10.1001/archsurg.1983.01390030060009.
Splenectomy increases the susceptibility to infections with certain bacteria, particularly Streptococcus pneumoniae. Because the immunomodulator Corynebacterium parvum expands the phagocytic cell compartment and enhances reticuloendothelial function, we tested the effect of C parvum in mice challenged with aerosolized pneumococci. Mice splenectomized seven days before pneumococcal challenge and treated intraperitoneally with 700 micrograms of C parvum immediately after exposure were protected when compared with splenectomized or sham-operated saline-injected controls. Analysis of proportional hazards showed the risk of dying in order of greatest to least as follows: splenectomy/saline, sham/saline, splenectomy/C parvum and sham/C parvum. The benefits of an intact spleen and C parvum seemed to be additive in their protective effects after aerosol pneumococcal challenge. After intravenous challenge, bloodstream clearance was improved in sham-operated mice at three days after C parvum injection compared with saline-injected sham-operated controls and C parvum-injected splenectomized mice. A significant improvement in bacterial clearance did not occur until seven days after C parvum treatment in splenectomized mice. The results demonstrate the value of a nonspecific immunomodulator for enhancing the defense mechanisms of both normal and splenectomized animals.
脾切除术会增加机体对某些细菌感染的易感性，尤其是肺炎链球菌。由于免疫调节剂短小棒状杆菌可扩大吞噬细胞池并增强网状内皮系统功能，我们测试了短小棒状杆菌对雾化肺炎球菌攻击的小鼠的影响。与接受脾切除术或假手术并注射生理盐水的对照组相比，在肺炎球菌攻击前7天进行脾切除术并在暴露后立即腹腔注射700微克短小棒状杆菌的小鼠受到了保护。比例风险分析显示，死亡风险从高到低依次为：脾切除/生理盐水组、假手术/生理盐水组、脾切除/短小棒状杆菌组和假手术/短小棒状杆菌组。在雾化肺炎球菌攻击后，完整脾脏和短小棒状杆菌的保护作用似乎具有相加性。静脉注射攻击后，与注射生理盐水的假手术对照组和注射短小棒状杆菌的脾切除小鼠相比，假手术小鼠在注射短小棒状杆菌后3天的血流清除率有所提高。在脾切除小鼠中，直到短小棒状杆菌治疗7天后细菌清除率才出现显著改善。结果表明，一种非特异性免疫调节剂对于增强正常动物和脾切除动物的防御机制具有重要价值。
