Arrowsmith M, Hadgraft J, Kellaway I W
Biochim Biophys Acta. 1983 Jan 7;750(1):149-56. doi: 10.1016/0005-2760(83)90214-x.
The thermodynamics of partitioning of some steroids into dimyristoylphosphatidylcholine (DMPC) liposomes determined above and below the phase-transition temperature (Tc) revealed that: (1) delta Gw leads to 1 for all steroids studied is negative. (2) The process is entropy dominated. (3) delta Hw leads to 1 and delta Sw leads to 1 is more positive below Tc than above it for C-21 steroids. (4) Partitioning occurs into areas slightly more hydrophilic than n-octanol. (5) Ketones substituted on the 11 position of a 21-OH steroid have greater hydrogen-bonding capability than 11-OH compounds. (6) Hydroxyl groups at different positions on the steroid nucleus are non-equivalent, and (7) The group contribution for 21-ester methylenes is greater than that reported for other solutes in DMPC liposome systems.
一些类固醇在相变温度（Tc）上下分配到二肉豆蔻酰磷脂酰胆碱（DMPC）脂质体中的热力学研究表明：（1）所有研究的类固醇的ΔGw→1均为负值。（2）该过程以熵为主导。（3）对于C-21类固醇，ΔHw→1和ΔSw→1在Tc以下比在Tc以上更正。（4）分配发生在比正辛醇稍亲水的区域。（5）21-OH类固醇11位上取代的酮比11-OH化合物具有更强的氢键能力。（6）类固醇核上不同位置的羟基不等效，并且（7）21-酯亚甲基的基团贡献大于DMPC脂质体系统中其他溶质的报道值。
