生理温度下胞嘧啶一水合物的脱水作用。
Dehydration of cytosine monohydrate at physiological temperatures.
作者信息
Martel P, Powell B M
出版信息
Biophys J. 1983 Jan;41(1):91-3. doi: 10.1016/S0006-3495(83)84409-9.
Abstract
Neutron diffraction, thermogravimetric, and mass spectrographic measurements have been used to show that cytosine monohydrate loses its water of hydration at physiological temperatures (approximately equal to 37 degrees C) and converts to cytosine. The "activation energy" for the dehydration process has been determined from isothermal weight curves and is 27.1 +/- 0.6 kcal . mol-1. It is suggested that pyrimidine dehydration may be involved in structural changes in DNA.
摘要
中子衍射、热重分析和质谱测量已被用于表明一水合胞嘧啶在生理温度（约等于37摄氏度）下失去其结晶水并转化为胞嘧啶。脱水过程的“活化能”已根据等温重量曲线确定，为27.1±0.6千卡·摩尔-1。有人提出嘧啶脱水可能与DNA的结构变化有关。
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本文引用的文献
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J Am Chem Soc. 1977 Aug 17;99(17):5545-50. doi: 10.1021/ja00459a002.
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Base crystallization and base stacking in water.水中的碱基结晶与碱基堆积
Eur J Biochem. 1979 May 15;96(2):213-9. doi: 10.1111/j.1432-1033.1979.tb13031.x.
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