Kuczenski R, Leith N J, Applegate C D
Brain Res. 1983 Jan 10;258(2):333-7. doi: 10.1016/0006-8993(83)91161-7.
The dose-dependent decrease in striatal dopamine (DA) metabolites following apomorphine (APO) administration was utilized as an index of changes in DA receptor sensitivity following the repeated administration of amphetamine (AMPH). The results suggest that: (a) repeated AMPH pretreatment does not alter DA autoreceptor sensitivity; and (b) interpretations of the decline in striatal DA metabolites at high doses of APO (greater than 50 micrograms/kg), in terms of activation of postsynaptic DA receptors, may require re-evaluation.
阿扑吗啡（APO）给药后纹状体多巴胺（DA）代谢产物的剂量依赖性降低被用作重复给予苯丙胺（AMPH）后DA受体敏感性变化的指标。结果表明：（a）重复AMPH预处理不会改变DA自身受体敏感性；（b）对于高剂量APO（大于50微克/千克）时纹状体DA代谢产物下降，依据突触后DA受体激活所做的解释可能需要重新评估。
