Chesnoy-Marchais D, Ascher P
Brain Res. 1983 Jan 17;259(1):57-67. doi: 10.1016/0006-8993(83)91066-1.
A study was made of the effects of various cations other than K+ on three K+ conductance increases induced by carbachol, histamine and dopamine in an identified group of Aplysia neurones: the 'A' neurones of the cerebral ganglion. The 3 responses were sensitive to alterations of both the extracellular and the intracellular concentrations of Na+ and Ca2+. In particular, they could be reduced markedly by: (a) lowering [Na]0 (replacing NaCl by either Tris-HCl, glucosamine chloride, MgCl2 or sucrose); (b) increasing [Na]i (by intracellular injection of Na+, or by blockade of the Na+-K+ pump); (c) increasing the extracellular divalent cation concentration; or (d) increasing [Ca]i4. Some of the effects of Na+ and divalent cations appear to occur on reaction steps common to the three K+ responses, while others probably imply reaction steps specific to one of the systems, since they differ according to the agonist used. The sensitivity to Na+ and Ca2+ of slow inhibitory responses due entirely to an increase in K+ conductance must be taken into account in the interpretation of some slow hyperpolarizing responses previously assumed to involve changes in Na+ conductance.
研究了除K+以外的各种阳离子对海兔特定神经元群（脑神经节的“A”神经元）中由卡巴胆碱、组胺和多巴胺诱导的三种K+电导增加的影响。这三种反应对细胞外和细胞内Na+和Ca2+浓度的变化敏感。特别是，它们可通过以下方式显著降低：(a) 降低[Na]0（用Tris-HCl、氨基葡萄糖氯化物、MgCl2或蔗糖替代NaCl）；(b) 增加[Na]i（通过细胞内注射Na+或通过阻断Na+-K+泵）；(c) 增加细胞外二价阳离子浓度；或(d) 增加[Ca]i4。Na+和二价阳离子的一些作用似乎发生在三种K+反应共有的反应步骤上，而其他作用可能意味着特定于其中一个系统的反应步骤，因为它们因所用激动剂而异。在解释一些先前假定涉及Na+电导变化的缓慢超极化反应时，必须考虑完全由K+电导增加引起的缓慢抑制反应对Na+和Ca2+的敏感性。
