Samura B A
Farmakol Toksikol. 1983 Jan-Feb;46(1):17-20.
Potassium salt of 8-bromotheophylline was made interact with alpha-bromoketones to obtain initial products (7-acylalkyl-8-bromotheophyllines) for the synthesis of the derivatives of 1H-imidazo(1,2-f)xanthine. 1-(beta-Oxyethyl)-2,3,6,8-tetramethylimidazo(1,2-f)xanthine and 1,2,6,8-tetramethylimidazo (1,2-f)xanthine were discovered to have a stimulant effect on the central nervous system, to increase the amplitude of evoked potentials of the visceral, auditory and cutaneous projection zones of the brain cortex, and to improve rhythm assimilation.
使8-溴茶碱钾盐与α-溴代酮相互作用，以获得用于合成1H-咪唑并(1,2-f)黄嘌呤衍生物的初始产物（7-酰基烷基-8-溴茶碱）。发现1-(β-氧乙基)-2,3,6,8-四甲基咪唑并(1,2-f)黄嘌呤和1,2,6,8-四甲基咪唑并(1,2-f)黄嘌呤对中枢神经系统有兴奋作用，可增加大脑皮层内脏、听觉和皮肤投射区诱发电位的幅度，并改善节律同化。
