[Effect of hypothermia and anti-angina preparations with malonate-like action on myocardial glycolysis and oxidative phosphorylation].

It has been discovered that hypothermia under 20 degrees C produces no effect on the reactions of anaerobic glycolysis and lactate level in the rat and dog myocardium during ischemia and anoxia. At the same time hypothermia reduces 8-10-fold the rate of free and conjugated mitochondrial respiration, which is similar to the malonate-like action of a number of antianginal drugs. Based on the fact that hypothermia protects the tissues from ischemic lesions it is concluded that inhibition of mitochondrial respiration with the drugs having a malonate-like action or with other mechanisms is to also protect the myocardium at early times of acute ischemia.