[己酮可可碱对氧合血红蛋白解离曲线的影响]
[Effect of pentoxifylline on the dissociation curve of oxyhemoglobin].
作者信息
Grandillo F, Giunta R, Scognamiglio G, Tirelli A, Coppola L, Torella R
出版信息
Farmaco Sci. 1983 Jan;38(1):29-34.
In 9 subjects with peripheral vascular insufficiencies the AA. have studied the behaviour of the oxyhaemoglobin dissociation curve before and after pentoxyphilline infusion. After this drug no variations were observed as it regards MCHC, 2-3-DPG and so on; however a positive correlation was found between 2-3-DPG and the Hill number. These results suggest that 2-3-DPG may influence the Hill number (which is the expression of the gradient of the oxyhaemoglobin dissociation curve) and therefore may interfere with O2 transport.
在9名患有外周血管功能不全的受试者中，研究人员研究了己酮可可碱输注前后氧合血红蛋白解离曲线的变化情况。输注该药物后，未观察到平均血红蛋白浓度（MCHC）、2,3-二磷酸甘油酸（2-3-DPG）等方面的变化；然而，发现2-3-DPG与希尔系数之间存在正相关。这些结果表明，2-3-DPG可能会影响希尔系数（它是氧合血红蛋白解离曲线斜率的一种表达），因此可能会干扰氧气运输。
Zotero 插件