Oertle M, Winterhalter K H, Di Iorio E E
FEBS Lett. 1983 Mar 7;153(1):213-6. doi: 10.1016/0014-5793(83)80150-1.
The replacement of O2 with CO was studied on cobalt-iron hemoglobin hybrids. Both proto- and mesocobalt hemes were used for the reconstitution. In the oxy quaternary conformation no difference is observed between alpha- and beta-subunits when only proto hemes are present in the hybrid (k4 = 30 s-1, k'4/l'4 = 2.5). If Co-meso heme is present on the beta-chains the binding properties of the partner subunit are modified (k'4/l'4 = 4).
在钴 - 铁血红蛋白杂种上研究了用一氧化碳取代氧气的过程。原钴血红素和中钴血红素都用于重组。在氧四级构象中，当杂种中仅存在原血红素时，α-和β-亚基之间未观察到差异（k4 = 30 s-1，k'4/l'4 = 2.5）。如果β链上存在中钴血红素，则伴侣亚基的结合特性会发生改变（k'4/l'4 = 4）。
