ATP、ADP和AMP对布氏毛霉乳酸脱氢酶活性的调节作用
ATP, ADP and AMP on the regulation of lactate dehydrogenase activity of Phycomyces blakesleeanus.
作者信息
Busto F, de Arriaga D, Soler J
出版信息
Int J Biochem. 1983;15(1):73-8. doi: 10.1016/0020-711x(83)90013-7.
PMID:6825905
Abstract
- The inhibition of ATP, ADP and AMP on lactate dehydrogenase activity from Phycomyces blakesleeanus was investigated kinetically at pH 6.0 and 7.5. 2. At pH 6.0 ATP was more effective as inhibitor than ADP and AMP. 3. All three nucleotides bind cooperatively to the enzyme, ATP and ADP decrease the positive homotropic interactions of NADH at pH 6.0. 4. The results obtained may contribute to explain the regulation of lactate dehydrogenase from Phycomyces blakesleeanus at acid pH values.
摘要
- 在pH 6.0和7.5条件下，对ATP、ADP和AMP对布氏毛霉乳酸脱氢酶活性的抑制作用进行了动力学研究。2. 在pH 6.0时，ATP作为抑制剂比ADP和AMP更有效。3. 所有三种核苷酸都与该酶协同结合，ATP和ADP在pH 6.0时降低了NADH的正向同促相互作用。4. 所得结果可能有助于解释布氏毛霉乳酸脱氢酶在酸性pH值下的调节机制。
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