Nardi J B
Dev Biol. 1983 Jan;95(1):163-74. doi: 10.1016/0012-1606(83)90015-5.
The neural pattern of the moth wing is a simple two-dimensional network nestled between the two epithelial monolayers that form the upper and lower surfaces of the wing. All neural elements within the wing blade are sensory and their axons grow proximally toward the mesothoracic ganglion. The sensory nerves of the wing are intimately associated with the basal lamina of the upper epithelial layer; and the molding of neural pattern is coupled with cues in the basal lamina. The global landscape of the basal lamina can be altered by exchange of epithelial grafts. Axons generally cross control grafts as well as grafts that have been displaced distally. However, axons generally avoid grafts that have been transposed proximally. This asymmetric response of growing axons implies that directional cues in the substratum are also asymmetric along the length of the wing. The asymmetric, graded distribution of extracellular matrix molecules associated with the basal lamina of the wing's upper epithelium could provide the short-range cues that guide sensory axons in a particular direction.
蛾类翅膀的神经模式是一个简单的二维网络，位于形成翅膀上、下表面的两个上皮单层之间。翅脉内的所有神经元件都是感觉性的，它们的轴突向近端生长，朝向中胸神经节。翅膀的感觉神经与上皮上层的基膜紧密相连；神经模式的形成与基膜中的线索相关。通过上皮移植可以改变基膜的整体格局。轴突通常会穿过对照移植以及向远端移位的移植。然而，轴突通常会避开向近端移位的移植。生长中的轴突的这种不对称反应意味着基质中的定向线索在翅膀长度方向上也是不对称的。与翅膀上皮上层基膜相关的细胞外基质分子的不对称、分级分布可能提供引导感觉轴突向特定方向生长的短程线索。
