Riva C E, Grunwald J E, Sinclair S H
Invest Ophthalmol Vis Sci. 1983 Jan;24(1):47-51.
The noninvasive Laser Doppler Velocimetry (LDV) technique was used in normal volunteers to determine retinal blood flow, F, during pure oxygen breathing at atmospheric pressure. Changes in blood flow were calculated based on Poiseuille relation, F = (pi D2/4) X Vmax, where Vmax is the red blood cell maximum or center-line velocity and D, the diameter of the vessel at the site of the LDV recordings. After five minutes of pure oxygen breathing, Vmax decreased by about 53%, vessel diameter by 12%, and retinal blood flow by about 60%. In arteries, pulsatility of red blood cell velocity (Vmax, systole/Vmax, diastole) during the cardiac cycle increased by about 10%. Decrease in red blood cell velocity was detectable within 1-1 1/2 min. From these LDV flow measurements and the changes in retinal mean circulation time (MCT) reported by other investigators, based on the relation F = v/MCT, a 45% decrease in retinal blood volume (v) during 100% O2 breathing was obtained.
非侵入性激光多普勒测速（LDV）技术被用于正常志愿者，以测定在常压下纯氧呼吸期间的视网膜血流量F。血流量的变化根据泊肃叶关系式F = (πD²/4)×Vmax进行计算，其中Vmax是红细胞最大速度或中心线速度，D是LDV记录部位血管的直径。在纯氧呼吸5分钟后，Vmax下降约53%，血管直径下降12%，视网膜血流量下降约60%。在动脉中，心动周期期间红细胞速度的搏动性（Vmax，收缩期/Vmax，舒张期）增加约10%。在1 - 1.5分钟内可检测到红细胞速度下降。根据这些LDV血流测量结果以及其他研究者报告的视网膜平均循环时间（MCT）变化，基于F = v/MCT的关系，得出在100%氧气呼吸期间视网膜血容量（v）下降45%。
