Rawlings C A, Keith J C, Lewis R E, Losonsky J M, McCall J W
J Am Vet Med Assoc. 1983 Jan 15;182(2):131-6.
The effects of aspirin and prednisolone in modifying the radiographic changes following adulticide treatment were studied in 3 groups of 6 dogs each. The dogs were radiographed and then 9 Dirofilaria immitis adults were surgically transplanted in each dog. All dogs were treated with thiacetarsamide 4 weeks later. One group received no additional treatment, the 2nd group received aspirin (10 mg/kg, daily for 4 weeks), and the 3rd group received prednisolone (1 mg/kg, daily for 4 weeks). Radiographs were taken at 1, 2, and 3 weeks after adulticide treatment, and the dogs were euthanatized at 4 weeks. The most consistent radiographic sign of pulmonary disease was a perivascular alveolar pattern in the caudal and accessory lung lobes. The right caudal lobe was the one most frequently affected. These parenchymal lesions were more frequent and more severe in the dogs given only adulticide treatment than in those given aspirin after adulticide treatment; the latter group in turn was more severely affected than the dogs given prednisolone after adulticide treatment. The radiographic evidence of pulmonary disease was resolving in most dogs at 3 weeks. The alveolar pattern on radiographs was distributed similarly to that observed at necropsy, using parenchymal uptake of Evan's blue as an indication of increased vascular permeability. Dissection of the perfusion-fixed lungs revealed that heartworms in 3 of the 6 dogs given prednisolone appeared to survive adulticide treatment.
在三组实验中，每组6只狗，研究了阿司匹林和泼尼松龙对成虫治疗后影像学变化的影响。对这些狗进行了X光检查，然后每只狗通过手术移植9条成年犬恶丝虫。4周后，所有的狗都接受了硫胂酰胺治疗。一组不接受额外治疗，第二组接受阿司匹林治疗（10毫克/千克，每天服用4周），第三组接受泼尼松龙治疗（1毫克/千克，每天服用4周）。在成虫治疗后的第1、2和3周拍摄X光片，并在第4周对狗实施安乐死。肺部疾病最一致的影像学表现是尾叶和副肺叶的血管周围肺泡模式。右尾叶是最常受影响的部位。与仅接受成虫治疗的狗相比，接受成虫治疗后再服用阿司匹林的狗的这些实质病变更频繁、更严重；后一组又比接受成虫治疗后服用泼尼松龙的狗受影响更严重。在3周时，大多数狗肺部疾病的影像学证据正在消退。X光片上的肺泡模式与尸检时观察到的相似，以伊文思蓝的实质摄取作为血管通透性增加的指标。对灌注固定的肺进行解剖发现，在接受泼尼松龙治疗的6只狗中，有3只的犬心丝虫似乎在成虫治疗后存活了下来。
