Lader M H
J Clin Psychiatry. 1983 Feb;44(2):47-53.
Insomnia--the chronic inability to obtain the amount and quality of sleep needed for effective daytime function--is a common subjective complaint. Several major causes exist, and many strategems can be used in management. When drugs are indicated, the benzodiazepines are the first choice. Flurazepam, a long-acting compound, has recently been complemented by temazepam, a shorter-acting hypnotic. The pharmacokinetics, actions, and clinical uses of temazepam are reviewed. It is concluded that temazepam is preferable where daytime alertness must be unimpaired, with flurazepam reserved for patients who need daytime sedation.
失眠——长期无法获得有效日间功能所需的睡眠量和睡眠质量——是一种常见的主观症状。其主要病因有多种，治疗上也有许多策略可用。如需使用药物，苯二氮䓬类药物是首选。长效化合物氟西泮，最近又有短效催眠药替马西泮作为补充。本文综述了替马西泮的药代动力学、作用及临床应用。得出的结论是，在必须不损害日间警觉性的情况下，替马西泮更为可取，而氟西泮则留给需要日间镇静的患者。
