Behrendt D M, Jochim K E
J Thorac Cardiovasc Surg. 1978 Sep;76(3):353-7.
This study tests the hypothesis that the efficacy of cardioplegic solution depends upon its chemical constituents rather than on its temperature alone. A standard preparation of right heart bypass in the dog was utilized. Left ventricular function curves were inscribed before and after 1 hour of aortic cross-clamping. No deterioration in function was observed in nonischemic control hearts or in hearts protected with cardioplegic solution consisting of potassium chloride (25 mEq. per liter) and mannitol (12.5 Gm. per liter in 5 percent dextrose and 0.2 percent saline at either 4 degrees C or 28 degrees C. Severe myocardial depression was observed in hearts rendered ischemic for 1 hour at 28 degrees C. without protection and also in hearts perfused with 5 percent dextrose and 0.2 percent saline at 28 degrees C. without the potassium chloride and mannitol. The evidence from this study indicates that cardioplegic solution exerts a protective effect beyond that which is afforded by hypothermia.
心脏停搏液的功效取决于其化学成分，而非仅仅取决于其温度。采用了犬右心旁路的标准制备方法。在主动脉交叉钳夹1小时前后记录左心室功能曲线。在非缺血对照心脏或用含氯化钾（每升25毫当量）和甘露醇（在5%葡萄糖和0.2%盐水中每升12.5克）的心脏停搏液在4℃或28℃下保护的心脏中，未观察到功能恶化。在28℃下缺血1小时且无保护的心脏以及在28℃下用5%葡萄糖和0.2%盐水灌注且无氯化钾和甘露醇的心脏中，观察到严重的心肌抑制。该研究的证据表明，心脏停搏液发挥的保护作用超出了低温所提供的保护作用。
