Renner E D, Helms C M, Johnson W, Tseng C H
J Clin Microbiol. 1983 Jan;17(1):146-8. doi: 10.1128/jcm.17.1.146-148.1983.
Serum samples from patients with documented influenza A virus infections were examined for antibodies to Legionella pneumophila and Mycoplasma pneumoniae to determine whether simultaneous or sequential infections with L. pneumophila and M. pneumoniae were complicating factors in influenza. When the frequency of copositivity of sera to influenza A virus and L. pneumophila was compared with the expected frequency for each infection alone, the difference was not statistically significant. However, when the frequency of copositivity of sera to influenza A virus and M. pneumoniae was compared with the expected frequency for each infection alone, there was a statistically significant (P less than 0.005) absence of coincident titers. Seasonal variations and differences in relative age frequencies for the two infections may partially explain the absence of coinfections. These data also suggest that in patients with either M. pneumoniae or influenza A virus infection, some type of protective mechanism which prevents coinfections with these organisms is present.
对确诊感染甲型流感病毒患者的血清样本进行检测，以确定其针对嗜肺军团菌和肺炎支原体的抗体，从而判断嗜肺军团菌和肺炎支原体的同时感染或相继感染是否为流感的并发症因素。将甲型流感病毒血清与嗜肺军团菌血清的共同阳性频率与每种感染单独出现时的预期频率进行比较，差异无统计学意义。然而，将甲型流感病毒血清与肺炎支原体血清的共同阳性频率与每种感染单独出现时的预期频率进行比较时，同时出现滴度的情况在统计学上有显著差异（P小于0.005）。两种感染的季节性变化以及相对年龄频率差异可能部分解释了合并感染的缺失。这些数据还表明，在肺炎支原体或甲型流感病毒感染患者中，存在某种防止与这些病原体合并感染的保护机制。
