Subrt P, Jorizzo J L, Apisarnthanarax P, Head E S, Smith E B
J Am Acad Dermatol. 1983 Jan;8(1):63-7. doi: 10.1016/s0190-9622(83)70008-3.
We present four cases of spreading pigmented actinic keratoses, an only recently described pigmented lesion of sun-exposed areas, in which the histologic appearance is that of actinic keratosis with the additional feature of excessive melanin deposition in the lower epidermis and in the upper dermis. Clinically, it is a brown patch or plaque with a smooth surface, usually larger than 1 cm, that tends to spread centrifugally. Clinical differential diagnoses include seborrheic keratosis, melanocytic nevus, senile lentigo, lentigo maligna, and lentigo maligna melanoma. This pigmented lesion is probably much more common than the existing literature would indicate.
我们报告了4例播散性色素性光化性角化病,这是一种最近才被描述的暴露于阳光下部位的色素性病变,其组织学表现为光化性角化病,伴有额外的特征,即表皮下部和真皮上部有过多的黑色素沉积。临床上,它是一个表面光滑的褐色斑片或斑块,通常大于1cm,倾向于离心性扩散。临床鉴别诊断包括脂溢性角化病、黑素细胞痣、老年性雀斑、恶性雀斑样痣和恶性雀斑样痣黑色素瘤。这种色素性病变可能比现有文献所显示的更为常见。