Karasawa T, Shikata T, Abe K, Horiuchi R, Takahashi T, Yoshihara N, Mayumi M, Suzuki H, Oda T
J Infect Dis. 1983 Feb;147(2):327-35. doi: 10.1093/infdis/147.2.327.
The protective efficacy of a hepatitis B vaccine against infections from transfusions of large volumes of highly infective blood in five immunized chimpanzees was assessed. Hepatitis B surface antigen (HBsAg) became positive and antibody to HBsAg (anti-HBs) disappeared soon after transfusion in the five chimpanzees. Two chimpanzees that had HBsAg only on the day of transfusion did not develop infection. However, the remaining three chimpanzees with persistent HBsAg antigenemia for three to four days developed serologic evidence of infection. Two chimpanzees did not have hepatitis and the third had a mild, transient case of acute hepatitis. The hepatitis B vaccine prevented the four immunized chimpanzees from developing illness. The remaining chimpanzee developed hepatitis, but a rapid booster response of anti-HBs owing to the previous vaccination appeared to lighten the severity of the disease and prevent chronicity.
评估了乙肝疫苗对五只免疫黑猩猩输注大量高传染性血液所致感染的保护效果。五只黑猩猩输血后不久，乙肝表面抗原（HBsAg）呈阳性，乙肝表面抗原抗体（抗-HBs）消失。仅在输血当天有HBsAg的两只黑猩猩未发生感染。然而，其余三只持续HBsAg抗原血症三至四天的黑猩猩出现了感染的血清学证据。两只黑猩猩未患肝炎，第三只出现了轻度、短暂的急性肝炎病例。乙肝疫苗使四只免疫黑猩猩未发病。其余一只黑猩猩患了肝炎，但由于之前接种疫苗，抗-HBs出现快速增强反应，似乎减轻了疾病的严重程度并预防了慢性化。
