Minchin M C, Williams J, Bowdler J M, Green A R
J Neurochem. 1983 Mar;40(3):765-8. doi: 10.1111/j.1471-4159.1983.tb08044.x.
The uptake and release of [3H]noradrenaline and [3H]-5-hydroxytryptamine (5-HT) were studied in cerebral cortex slices from rats 30 min and 24 h after a single electroconvulsive shock (ECS) and 24 h after a series of five shocks given over 10 days. Both the Km and Vmax for 5-HT uptake were lower than controls 24 h after a single ECS, whereas after 5 ECS spread over 10 days both parameters remained depressed, though only the fall in Vmax was significant. Noradrenaline uptake was not altered after a single ECS, but the Vmax and Km were elevated following chronic ECS treatment. Neither ECS treatment schedule had any effect on the potassium-stimulated release of either transmitter. It is possible that the changes in monoamine uptake seen following ECS are an adaptive response to alterations in the synaptic cleft concentration of these transmitters.
在单次电惊厥休克（ECS）后30分钟和24小时以及在10天内给予一系列五次休克后24小时，研究了大鼠大脑皮层切片中[3H]去甲肾上腺素和[3H] - 5 - 羟色胺（5 - HT）的摄取和释放。单次ECS后24小时，5 - HT摄取的Km和Vmax均低于对照组，而在10天内给予5次ECS后，尽管只有Vmax的下降具有统计学意义，但这两个参数仍保持降低。单次ECS后去甲肾上腺素摄取未改变，但慢性ECS治疗后Vmax和Km升高。两种ECS治疗方案对任何一种递质的钾刺激释放均无影响。ECS后所见单胺摄取的变化可能是对这些递质突触间隙浓度改变的一种适应性反应。
