Peterson E W, Cardoso E R
J Neurosurg. 1983 Mar;58(3):338-44. doi: 10.3171/jns.1983.58.3.0338.
In three groups of cats, the authors studied the effect of subarachnoid hemorrhage (SAH) on the permeability of the blood-brain barrier (BBB) to the penetration of Evans blue-protein complex. One group received arterial hypertension alone, one group SAH alone, and one group SAH followed by arterial hypertension. Animals subjected to arterial hypertension alone showed areas of BBB breakdown. However, when cats were rendered hypertensive after SAH, there were no demonstrable BBB lesions. The SAH was produced by intracisternal injection of whole blood and hypertension by the intravenous injection of metaraminol. The preservation of the BBB after SAH is discussed. Vasospasm is considered as a possible hemodynamic variable responsible for the protection of the BBB from hypertensive damage. The need for a new model is proposed to further investigate the state of the BBB after SAH.
在三组猫中，作者研究了蛛网膜下腔出血（SAH）对血脑屏障（BBB）对伊文思蓝 - 蛋白质复合物渗透的通透性的影响。一组仅接受动脉高血压，一组仅接受SAH，另一组先接受SAH然后接受动脉高血压。仅接受动脉高血压的动物出现了血脑屏障破坏区域。然而，当猫在SAH后出现高血压时，未发现明显的血脑屏障损伤。通过脑池内注射全血产生SAH，通过静脉注射间羟胺产生高血压。讨论了SAH后血脑屏障的保存情况。血管痉挛被认为是可能保护血脑屏障免受高血压损伤的血流动力学变量。提出需要一个新模型来进一步研究SAH后血脑屏障的状态。
