Dewey D L, Gaugas J M, Stratford M R, Minchinton A I
J Pathol. 1983 Feb;139(2):141-9. doi: 10.1002/path.1711390205.
The toxicity to cultured cells of the cancer chemotherapeutic agent methylglyoxal-bis[guanylhydrazone] (MGBG) varies considerably between different cell lines and is always more toxic in the absence of exogenous polyamine. We have looked at the relative MGBG toxicity of two different murine melanoma tumour cell lines (Harding-Passey and Cloudman) and normal murine fibroblasts, and found wide variation with no correlation in sensitivity to MGBG between tumour and normal cells. High sensitivity to MGBG may be associated with high transport across the cell membrane.
癌症化疗药物甲基乙二醛双[脒腙]（MGBG）对培养细胞的毒性在不同细胞系之间差异很大，并且在没有外源性多胺的情况下毒性总是更大。我们研究了两种不同的小鼠黑色素瘤肿瘤细胞系（哈丁-帕西和克劳德曼）和正常小鼠成纤维细胞对MGBG的相对毒性，发现差异很大，肿瘤细胞和正常细胞对MGBG的敏感性之间没有相关性。对MGBG的高敏感性可能与跨细胞膜的高转运有关。
