Moltmann U G, Mehlhorn H, Schein E, Rehbein G, Voigt W P, Zweygarth E
J Parasitol. 1983 Feb;69(1):111-20.
The development of Babesia equi (Piroplasmia) in the vertebrate host was studied by electron microscopy. The tick-borne sporozoites initiated an exoerythrocytic schizogony in lymphocytes in vivo and in vitro. In lymphocyte cultures the schizonts of B. equi lay as fissured bodies directly within the host cell forming numerous cytomeres. These cytomeres were bordered by a single membrane and contained polymorphous nuclei. Merozoite differentiation was initiated at several places by protrusions appearing at the periphery of the cytomeres. The cytoplasm of the schizont merged progressively into the young merozoites. The mature merozoites were pear-shaped (2.0 X 1.5 microns), bounded by a pellicle and had an apical complex without conoid. Numerous merozoites were observed entering erythrocytes in vitro. In vivo, lymphocytes containing B. equi schizonts were seen in capillaries within lymph nodes from the 12th day onwards after attachment of infected ticks. At the same time some erythrocytes were found that contained B. equi merozoites. Development of B. equi in the vertebrate host shows many similarities to the corresponding development of Theileria parasites. This makes a new discussion of the taxonomic position of B. equi necessary.
通过电子显微镜研究了马巴贝斯虫（梨形虫）在脊椎动物宿主体内的发育过程。蜱传播的子孢子在体内和体外的淋巴细胞中引发了红细胞外裂殖生殖。在淋巴细胞培养物中，马巴贝斯虫的裂殖体以有裂缝的体形式直接存在于宿主细胞内，形成许多裂殖子。这些裂殖子被单层膜包围，含有多形核。裂殖子的分化在几个部位由裂殖子周边出现的突起开始。裂殖体的细胞质逐渐融入年轻的裂殖子中。成熟的裂殖子呈梨形（2.0×1.5微米），由表膜界定，有一个无类锥体的顶复合器。在体外观察到许多裂殖子进入红细胞。在体内，从感染蜱附着后的第12天起，在淋巴结内的毛细血管中可见含有马巴贝斯虫裂殖体的淋巴细胞。同时发现一些红细胞含有马巴贝斯虫裂殖子。马巴贝斯虫在脊椎动物宿主体内的发育与泰勒虫寄生虫的相应发育有许多相似之处。这使得有必要重新讨论马巴贝斯虫的分类地位。
