Hiejima K, Suzuki F, Takahashi M, Satake S
Jpn Circ J. 1983 Jan;47(1):98-104. doi: 10.1253/jcj.47.98.
The effects of the intravenous administration of three drugs, i.e., verapamil, disopyramide, and procainamide, on paroxysmal supraventricular tachycardia (PSVT), atrial fibrillation (Af) and atrial flutter (AF) were evaluated electrophysiologically. Efficacy on PSVT was 94.7% (36/38) with verapamil, 61.5% (13/18) with disopyramide and 100% (4/4) with procainamide. Efficacy on Af and AF was 9.1% (1/11) with verapamil and 80.0% (12/15) with disopyramide. PSVT termination mechanisms were as follows: 1) Verapamil: A-H block in 5 cases and H-A block in 5 cases with Type 1 A-V nodal reentrant tachycardia (AVNRT). H-A block in 6 cases with Type 2 and Type 3. A-H block in 17 of 18 cases with A-V reciprocating tachycardia (AVRT). Cycle length alternans were observed in 13 of 34 cases. 2) Disopyramide: H-A block in 2 cases with AVNRT and V-A block in 2 cases with AVRT. 3) Procainamide: V-A block in 4 cases with AVRT. These results suggest that verapamil and disopyramide are most effective on PSVT and Af, respectively.
通过电生理学方法评估了静脉注射维拉帕米、丙吡胺和普鲁卡因胺这三种药物对阵发性室上性心动过速（PSVT）、心房颤动（Af）和心房扑动（AF）的影响。维拉帕米对阵发性室上性心动过速的有效率为94.7%（36/38），丙吡胺为61.5%（13/18），普鲁卡因胺为100%（4/4）。维拉帕米对心房颤动和心房扑动的有效率为9.1%（1/11），丙吡胺为80.0%（12/15）。阵发性室上性心动过速的终止机制如下：1）维拉帕米：1型房室结折返性心动过速（AVNRT）中5例出现A-H阻滞，5例出现H-A阻滞；2型和3型中6例出现H-A阻滞；房室折返性心动过速（AVRT）的18例中有17例出现A-H阻滞。34例中有13例观察到周期长度交替。2）丙吡胺：房室结折返性心动过速中2例出现H-A阻滞，房室折返性心动过速中2例出现V-A阻滞。3）普鲁卡因胺：房室折返性心动过速中4例出现V-A阻滞。这些结果表明，维拉帕米和丙吡胺分别对阵发性室上性心动过速和心房颤动最有效。
