Simpson C F, Cardeilhac P T
Proc Soc Exp Biol Med. 1983 Feb;172(2):168-72. doi: 10.3181/00379727-172-41541.
Broad-Breasted White turkeys were randomized into four treatment groups at 4 weeks of age in each of three trials. Group 1, males, and Group 2, females, were fed an unsupplemented (control) diet from 4 to 10 weeks of age. Group 3, males, and Group 4, females, were fed the control diet supplemented with 0.07% beta-aminopropionitrile (BAPN). The experiments were terminated at 10 weeks of age. There was no mortality among male and female turkeys fed the control diet or significant differences in blood pressure, heart rate, aortic tensile strength, or aortic hydroxyproline between these males and females. Sixty-five percent of the males and 21% of the females fed BAPN died of dissecting aneurysms; blood pressure, heart rate, and dp/dt max were not altered as a result of feeding BAPN. Aortic tensile strength was higher in control turkeys than those fed BAPN, but males fed BAPN had the lowest value. Males fed BAPN also had the lowest aortic hydroxyproline content. Ultrastructural alterations of aortic elastic and collagen fibers were more severe in males than females fed BAPN. Aortic changes did not occur in control turkeys.
在三项试验中，宽胸白羽火鸡在4周龄时被随机分为四个处理组。第1组为雄性，第2组为雌性，从4周龄到10周龄饲喂未添加（对照）日粮。第3组为雄性，第4组为雌性，饲喂添加了0.07%β-氨基丙腈（BAPN）的对照日粮。实验在10周龄时终止。饲喂对照日粮的雄性和雌性火鸡之间没有死亡情况，并且这些雄性和雌性火鸡在血压、心率、主动脉抗张强度或主动脉羟脯氨酸方面没有显著差异。饲喂BAPN的雄性火鸡中有65%、雌性火鸡中有21%死于夹层动脉瘤；饲喂BAPN并未改变血压、心率和dp/dt max。对照火鸡的主动脉抗张强度高于饲喂BAPN的火鸡，但饲喂BAPN的雄性火鸡的值最低。饲喂BAPN的雄性火鸡的主动脉羟脯氨酸含量也最低。饲喂BAPN的雄性火鸡主动脉弹性纤维和胶原纤维的超微结构改变比雌性更严重。对照火鸡未出现主动脉变化。
