Lichtenberger L M, Graziani L A, Dial E J, Butler B D, Hills B A
Science. 1983 Mar 18;219(4590):1327-9. doi: 10.1126/science.6828859.
Intragastric administration of a liposomal surfactant suspension markedly reduced acid-induced gastric ulcerogenesis and bleeding in rats. The concentration of surface-active molecules intrinsically present in the gastric mucosa was increased two to six times by administration of 16,16-dimethyl prostaglandin E2. Thus, local accumulation of surface-active phospholipids may be an integral component of the cytoprotective mechanism activated by prostaglandin treatment.
胃内给予脂质体表面活性剂混悬液可显著减少大鼠酸诱导的胃溃疡形成和出血。通过给予16,16-二甲基前列腺素E2，胃黏膜中固有存在的表面活性分子浓度增加了2至6倍。因此，表面活性磷脂的局部蓄积可能是前列腺素治疗激活的细胞保护机制的一个组成部分。
