Smith S D, Kimberling W J, Pennington B F, Lubs H A
Science. 1983 Mar 18;219(4590):1345-7. doi: 10.1126/science.6828864.
Linkage analysis in families with apparent autosomal dominant reading disability produced a lod score of 3.241. Since the traditionally accepted significance level for linkage is a lod score of 3.0, these results strongly suggest that a gene playing a major etiologic role in one form of reading disability is on chromosome 15.
对明显为常染色体显性遗传阅读障碍的家族进行连锁分析，得到的对数优势比分数为3.241。由于传统上认可的连锁显著水平是对数优势比分数为3.0，因此这些结果有力地表明，在一种阅读障碍形式中起主要病因作用的一个基因位于15号染色体上。
