小鼠体内氯化萘的组织分布与消除

Tissue distribution and elimination of chlorinated naphthalenes in mice.

作者信息

Oishi H, Oishi S

出版信息

Toxicol Lett. 1983 Feb;15(2-3):119-22. doi: 10.1016/0378-4274(83)90204-7.

Abstract

Male pathogen-free JCL:ICR mice were dosed i.p. 1 mg of 1,8-and 2,7-dichloronaphthalenes and octachloronaphthalene dissolved in olive oil. The highest levels of all chlorinated naphthalenes were found in adipose tissue. The biological half-life of octachloronaphthalene was longer than both dichloronaphthalenes while the half-life of 2,7-dichloronaphthalene was longer than that of 1,8-dichloronaphthalene in most tissues.

摘要

雄性无特定病原体的JCL:ICR小鼠经腹腔注射1毫克溶解于橄榄油中的1,8-二氯萘、2,7-二氯萘和八氯萘。在脂肪组织中发现了所有氯化萘的最高含量。八氯萘的生物半衰期比两种二氯萘都长，而在大多数组织中，2,7-二氯萘的半衰期比1,8-二氯萘长。