Bünger C, Hjermind J, Bülow J
Acta Orthop Scand. 1983 Feb;54(1):80-7. doi: 10.3109/17453678308992873.
The relationships between intraosseous pressure and regional blood flow in the juxta-articular epiphyses were determined in the knees of immature dogs. Intraosseous pressures were continuously registered in one knee. Regional blood flow rates were simultaneously determined by the microsphere technique before and after venous tamponade of both knee joint capsules. During complete venous tamponade the intraosseous pressure of the distal femoral epiphyses rose 268%, while flow increased 122%. A concurrent 20-fold flow increase of the knee capsule and 3-4-fold flow increase of the proximal femoral bone was observed. Evacuation of the knee joints resulted in an immediate drop of the intraosseous pressure of the distal femoral epiphyses, whereas hyperaemia prevailed for at least half an hour and was most pronounced in the distal femoral epiphyses and knee joint capsule. Intraosseous pressure registration did not significantly influence regional blood flow. It is suggested that the changes of intraosseous pressures during knee joint tamponade reflect changes in the venous outlet resistance. The results demonstrate the significance of intra-articular pressure increase on the hemodynamics of the juxta-articular tissues of the knee and proximal femoral bone. These findings may be of importance in the pathogenesis of growth disturbances observed in juvenile degenerative arthritis.
在未成熟犬的膝关节中测定了关节周围骨骺内骨内压与局部血流之间的关系。在一侧膝关节连续记录骨内压。在双侧膝关节囊静脉压迫前后，通过微球技术同时测定局部血流速率。在完全静脉压迫期间，股骨远端骨骺的骨内压升高268%，而血流增加122%。同时观察到膝关节囊血流增加20倍，股骨近端骨血流增加3 - 4倍。膝关节排空导致股骨远端骨骺骨内压立即下降，而充血持续至少半小时，在股骨远端骨骺和膝关节囊中最为明显。骨内压记录对局部血流没有显著影响。提示膝关节压迫期间骨内压的变化反映了静脉流出阻力的变化。结果表明关节内压力升高对膝关节和股骨近端关节周围组织血流动力学的重要性。这些发现可能对青少年退行性关节炎中观察到的生长障碍的发病机制具有重要意义。
