Hasstedt S J, Meyers D A, Marsh D G
Am J Med Genet. 1983 Jan;14(1):61-6. doi: 10.1002/ajmg.1320140110.
Total serum immunoglobulin E (IgE) concentration was measured on 316 members of five pedigrees selected through breast cancer probands. Sex- and age-adjusted natural logarithm-transformed IgE level was not found to differ between individuals with breast cancer or with cancer of any site and other relatives. Likelihoods of the polygenic and of one-locus, two-allele major gene and mixed models were computed. The analysis provided evidence for the presence of a polygenic component in the determination of IgE; it did not show evidence of a major gene effect.
对通过乳腺癌先证者选择的五个家系中的316名成员测定了血清总免疫球蛋白E（IgE）浓度。未发现乳腺癌患者或任何部位癌症患者与其他亲属之间经性别和年龄调整的自然对数转换IgE水平存在差异。计算了多基因模型、单基因双等位基因模型和混合模型的似然性。分析为IgE测定中存在多基因成分提供了证据；未显示出主基因效应的证据。
