Lien E L
Metabolism. 1978 Sep;27(9):1095-100. doi: 10.1016/0026-0495(78)90155-5.
The glucose response to arginine infusion in normal rats was studied during insulin and glucagon deficiency (somatostatin infusion, 1 mg/kg/hr) or selective glucagon deficiency ([D-Cys14]-somatostain infusion, 1 mg/kg/hr). In control studies, plasma glucose levels rose 14 mg/dl in response to arginine and returned to basal levels at the termination of the infusion. Insulin levels increased 136 +/- 12 muU/ml and glucagon increased 76 +/- 12 pg/ml during the infusion. Infusion of somatostatin resulted in supression of both arginine-induced insulin and arginine-induced glucagon release, and marked hyperglycemia ensued. The administration of [D-Cys14]-somatostatin during arginine infusion produced no associated hyperglycemia. It resulted in suppression of glucagon secretion and a modest rise in insulin release. These results demonstrate that the hyperglycemic effects of somatostatin in arginine-treated animals do not arise in animals treated with glucagon-specific somatostatin analogs.
在胰岛素和胰高血糖素缺乏（输注生长抑素，1毫克/千克/小时）或选择性胰高血糖素缺乏（输注[D-半胱氨酸14]-生长抑素，1毫克/千克/小时）的情况下，研究了正常大鼠对精氨酸输注的葡萄糖反应。在对照研究中，精氨酸输注后血浆葡萄糖水平升高14毫克/分升，并在输注结束时恢复到基础水平。输注期间胰岛素水平升高136±12微单位/毫升，胰高血糖素升高76±12皮克/毫升。输注生长抑素导致精氨酸诱导的胰岛素和精氨酸诱导的胰高血糖素释放均受到抑制，随后出现明显的高血糖。在精氨酸输注期间给予[D-半胱氨酸14]-生长抑素未产生相关的高血糖。它导致胰高血糖素分泌受到抑制，胰岛素释放略有升高。这些结果表明，生长抑素在精氨酸处理动物中的高血糖作用在用胰高血糖素特异性生长抑素类似物处理的动物中不会出现。
