大鼠中硫喷妥钠和芬太尼的最低肺泡有效浓度值。

MAC values of thiopental and fentanyl in rats.

作者信息

Shingu K, Eger E I, Johnson B H, Lurz F W, Hickey R F

出版信息

Anesth Analg. 1983 Feb;62(2):151-4.

Abstract

A comparison of the effects of thiopental or fentanyl with those of inhaled anesthetics requires the establishment of a comparable level of anesthetic potency. Accordingly, using the response of male Sprague-Dawley rats to tail-clamping, we determined the ED50S for thiopental and fentanyl. Half of the rats were pretreated with phenobarbital. After subcutaneous injection of various doses of thiopental or fentanyl, each rat was tested for movement in response to tail-clamping at 15-min intervals for 2 h. In untreated rats, the maximal effect of thiopental (i.e., the lowest ED50 value was 107 +/- 10 mg/kg, mean +/- SEM) occurred 75 min after injection. Although higher values were found at other times, differences from the nadir were relatively small. In rats pretreated with phenobarbital, the lowest value (130 +/- 8 mg/kg) occurred at 60 min. The lowest ED50S for fentanyl (52 +/- 7 micrograms/kg for control rats, and 73 +/- 14 micrograms/kg for pretreated rats) were found at 15 min.

摘要

比较硫喷妥钠或芬太尼与吸入麻醉剂的效果需要建立相当的麻醉效能水平。因此，利用雄性斯普拉格-道利大鼠对夹尾的反应，我们测定了硫喷妥钠和芬太尼的半数有效剂量（ED50）。半数大鼠用苯巴比妥预处理。皮下注射不同剂量的硫喷妥钠或芬太尼后，每隔15分钟对每只大鼠进行夹尾测试，持续2小时，观察其运动反应。在未处理的大鼠中，硫喷妥钠的最大效应（即最低ED50值为107±10mg/kg，均值±标准误）在注射后75分钟出现。虽然在其他时间发现了更高的值，但与最低点的差异相对较小。在用苯巴比妥预处理的大鼠中，最低值（130±8mg/kg）出现在60分钟时。芬太尼的最低ED50（对照大鼠为52±7μg/kg，预处理大鼠为73±14μg/kg）在15分钟时出现。