萘夫西林引起的血小板功能障碍和出血。
Nafcillin-induced platelet dysfunction and bleeding.
作者信息
Alexander D P, Russo M E, Fohrman D E, Rothstein G
出版信息
Antimicrob Agents Chemother. 1983 Jan;23(1):59-62. doi: 10.1128/AAC.23.1.59.
Abstract
This paper describes two cases of nafcillin-induced platelet dysfunction, with positive rechallenge data for one patient. Nafcillin resulted in abnormal bleeding times in both patients and a clinically apparent bleeding episode in one of the cases. Platelet function tests were performed on one patient during the initial therapy and after rechallenge with nafcillin. Platelet aggregation showed abnormal responses to ADP, collagen, and epinephrine. Platelet count and morphology were normal. Nafcillin should be recognized as another antibiotic which causes platelet function abnormalities and clinical bleeding episodes.
摘要
本文描述了两例萘夫西林引起的血小板功能障碍病例，其中一例患者再次用药试验数据呈阳性。萘夫西林导致两名患者的出血时间均异常，其中一例出现了明显的临床出血事件。对一名患者在初始治疗期间及再次使用萘夫西林后进行了血小板功能测试。血小板聚集试验显示，该患者对二磷酸腺苷、胶原和肾上腺素的反应异常。血小板计数和形态均正常。萘夫西林应被视为另一种可导致血小板功能异常和临床出血事件的抗生素。
相似文献
1
Nafcillin-induced platelet dysfunction and bleeding.萘夫西林引起的血小板功能障碍和出血。
Antimicrob Agents Chemother. 1983 Jan;23(1):59-62. doi: 10.1128/AAC.23.1.59.
2
Impaired platelet function associated with parenteral nafcillin.与胃肠外应用萘夫西林相关的血小板功能受损。
Ann Clin Lab Sci. 1990 Jan-Feb;20(1):79-84.
3
Effect of drug-induced platelet dysfunction on surgical bleeding.药物诱导的血小板功能障碍对手术出血的影响。
Am J Surg. 1982 Feb;143(2):215-7. doi: 10.1016/0002-9610(82)90071-x.
4
Acquired platelet dysfunction following mithramycin therapy.光辉霉素治疗后获得性血小板功能障碍。
Cancer. 1978 Feb;41(2):448-54. doi: 10.1002/1097-0142(197802)41:2<448::aid-cncr2820410211>3.0.co;2-u.
5
Exaggeration of defective platelet function by methyldopa in hypothyroidism.甲基多巴对甲状腺功能减退症患者血小板功能缺陷的夸大作用。
Am J Hematol. 1984 Aug;17(2):209-15. doi: 10.1002/ajh.2830170213.
6
Haemostatic abnormalities in treatment-naïve patients with Type 1 Gaucher's disease.初治 1 型戈谢病患者的止血异常。
Platelets. 2012;23(2):143-9. doi: 10.3109/09537104.2011.597526. Epub 2011 Jul 19.
7
Inherited heterogenous defect in platelet aggregation selectively with ADP and epinephrine--a series of 25 cases.血小板聚集存在遗传性异质性缺陷，对ADP和肾上腺素呈选择性——25例病例系列
Indian J Pathol Microbiol. 2005 Jul;48(3):345-8.
8
The clinical relevance of platelet aggregation study in myeloproliferative disorders.骨髓增殖性疾病中血小板聚集研究的临床相关性。
Ann Acad Med Singap. 1983 Jul;12(3):466-71.
9
Platelet dysfunction in patients with vitamin B12 deficiency.维生素B12缺乏患者的血小板功能障碍。
Acta Haematol. 1979;61(2):75-9. doi: 10.1159/000207635.
10
Postoperative hemorrhage associated with carbenicillin administration. Report of two cases and review of the literature.羧苄青霉素应用相关的术后出血。两例报告并文献复习。
Am J Surg. 1977 Nov;134(5):630-4. doi: 10.1016/0002-9610(77)90451-2.
引用本文的文献
1
Worldwide assessment of linezolid's clinical safety and tolerability: comparator-controlled phase III studies.利奈唑胺临床安全性和耐受性的全球评估：对照比较的III期研究
Antimicrob Agents Chemother. 2003 Jun;47(6):1824-31. doi: 10.1128/AAC.47.6.1824-1831.2003.
2
Hematologic effects of linezolid: summary of clinical experience.利奈唑胺的血液学效应：临床经验总结
Antimicrob Agents Chemother. 2002 Aug;46(8):2723-6. doi: 10.1128/AAC.46.8.2723-2726.2002.
3
In vitro and in vivo studies of the effect of aztreonam on platelet function and coagulation in normal volunteers.氨曲南对正常志愿者血小板功能和凝血影响的体外和体内研究。
Antimicrob Agents Chemother. 1986 Jul;30(1):73-7. doi: 10.1128/AAC.30.1.73.
本文引用的文献
1
The partial thromboplastin time with kaolin. A simple screening test for first stage plasma clotting factor deficiencies.高岭土部分凝血活酶时间。用于筛查第一阶段血浆凝血因子缺乏症的简单检测。
Am J Clin Pathol. 1961 Sep;36:212-9. doi: 10.1093/ajcp/36.3.212.
2
Effects of sodium piperacillin on platelet function in normal volunteers.哌拉西林钠对正常志愿者血小板功能的影响。
Antimicrob Agents Chemother. 1981 Apr;19(4):532-3. doi: 10.1128/AAC.19.4.532.
3
Coagulopathy associated with the use of moxalactam.
JAMA. 1982 Sep 3;248(9):1100.
4
Platelet counts with the Coulter counter.使用库尔特计数器进行血小板计数。
Am J Clin Pathol. 1965 Dec;44(6):678-88. doi: 10.1093/ajcp/44.6.678.
5
The standardized normal Ivy bleeding time and its prolongation by aspirin.标准化的常春藤出血时间及其因阿司匹林而延长的情况。
Blood. 1969 Aug;34(2):204-15.
6
Laboratory tests of platelet function.
Ann Clin Lab Sci (1971). 1972 Jan-Feb;2(1):63-74.
7
The hemostatic defect produced by carbenicillin.羧苄青霉素产生的止血缺陷。
N Engl J Med. 1974 Aug 8;291(6):265-70. doi: 10.1056/NEJM197408082910601.
8
The effect of carbenicillin on the haemostatic mechanism.羧苄青霉素对止血机制的影响。
J Pharm Pharmacol. 1973 Nov;25(11):876-80. doi: 10.1111/j.2042-7158.1973.tb09966.x.
9
Defective platelet function following the administration of penicillin compounds.青霉素类化合物给药后血小板功能缺陷。
Blood. 1976 Jun;47(6):949-56.
10
Influence of cephalosporin antibiotics on blood coagulation and platelet function.头孢菌素类抗生素对血液凝固及血小板功能的影响。
Antimicrob Agents Chemother. 1976 Jan;9(1):91-3. doi: 10.1128/AAC.9.1.91.
Zotero 插件