Newsome A L, Wilhelm W E
Appl Environ Microbiol. 1983 Feb;45(2):665-8. doi: 10.1128/aem.45.2.665-668.1983.
Deferrioxamine B and rhodotorulic acid, iron-chelating agents of microbial origin, exerted a pronounced inhibitory effect on pathogenic Naegleria fowleri at microgram levels. This inhibition was diminished by adding iron to the chelators before incubation with Naegleria isolates. These and related microbial iron chelators occur naturally in the environment. This could be of considerable ecological significance and provides a novel hypothesis to account for the proliferation of pathogenic Naegleria spp. in certain aquatic habitats.
去铁胺B和红酵母酸是微生物来源的铁螯合剂，在微克水平上对致病性福氏耐格里阿米巴有显著的抑制作用。在与耐格里阿米巴分离株孵育前向螯合剂中添加铁，这种抑制作用就会减弱。这些以及相关的微生物铁螯合剂在环境中天然存在。这可能具有相当大的生态意义，并为解释致病性耐格里阿米巴属在某些水生栖息地的增殖提供了一个新的假说。
