Desa D J
Arch Dis Child. 1983 Jan;58(1):24-8. doi: 10.1136/adc.58.1.24.
The histological findings in the middle ear cavity of 72 infants of varying gestations, birthweights, and ages are presented. All infants died after receiving ventilatory support and oxygen for longer than 14 days. In 5 infants there was no detectable histological abnormality. In the remainder, a wide range of lesions was seen including glandular metaplasia, retained squamous debris, squamous polyps, otitis media, and destruction of ossicles. None of the cases of otitis media was diagnosed before necropsy; all were associated with pneumonia. No single specific infectious agent predominated. Several factors could contribute to the spectrum of lesions, and these include persistent amniotic squamous debris, infection, and the effects of oxygen and a nasal airway. The possible implications of these findings are discussed, and it is argued that similar changes of lesser severity could be present in survivors in whom otitis media and conduction hearing defects could be expected.
本文呈现了72例不同孕周、出生体重和年龄的婴儿中耳腔的组织学检查结果。所有婴儿在接受通气支持和吸氧超过14天后死亡。5例婴儿未发现可检测到的组织学异常。其余婴儿则出现了广泛的病变，包括腺化生、残留鳞状上皮碎屑、鳞状息肉、中耳炎和听小骨破坏。所有中耳炎病例在尸检前均未被诊断出；均与肺炎相关。没有单一特定的感染因子占主导。有几个因素可能导致病变范围，包括持续性羊水鳞状上皮碎屑、感染以及氧气和鼻气道的影响。文中讨论了这些发现可能的影响，并认为在预期会出现中耳炎和传导性听力缺陷的存活者中可能存在程度较轻的类似变化。
