Ozdamar O, Kraus N
Audiology. 1983;22(1):34-49. doi: 10.3109/00206098309072768.
Middle-latency responses (MLR) in humans were studied using an unconventional recording technique with wide bandpass filters. Such filtering permitted simultaneous recording of the auditory brain stem response (ABR) thus facilitating comparisons between the two responses. Effects of sedation (chloral hydrate and diazepam), stimulus-related properties and the coronal distribution of MLRs were examined. Mild sedatives did not appear to affect either MLRs or ABRs. MLRs differed from ABRs in their stimulus-related properties, implying that the neuronal mechanisms underlying their generation are not the same. The amplitude of the MLR component, Pa, was largest at the vertex and symmetrically distributed over the temporal lobes. MLR components Na and Pa and ABR wave V were reliably obtained in all subjects at moderate and high stimulus intensities. At low stimulus levels, however, the detectability of wave V was more robust than the middle-latency components. Thus ABR appears to be the test of choice when hearing sensitivity is in question. MLRs are likely to be most clinically useful in patients with neurological or central auditory processing disorders.
使用带有宽带通滤波器的非常规记录技术对人类的中潜伏期反应（MLR）进行了研究。这种滤波允许同时记录听性脑干反应（ABR），从而便于比较这两种反应。研究了镇静作用（水合氯醛和地西泮）、刺激相关特性以及MLR的冠状分布。轻度镇静剂似乎对MLR或ABR均无影响。MLR在其刺激相关特性方面与ABR不同，这意味着它们产生的神经元机制并不相同。MLR成分Pa的振幅在头顶最大，并在颞叶对称分布。在中等和高刺激强度下，所有受试者均能可靠地获得MLR成分Na和Pa以及ABR波V。然而，在低刺激水平时，波V的可检测性比中潜伏期成分更强。因此，当听力敏感性存在疑问时，ABR似乎是首选测试。MLR在患有神经或中枢听觉处理障碍的患者中可能在临床上最有用。
