钙调蛋白中依赖温度的构象变化。
Temperature dependent conformational changes in calmodulin.
作者信息
Gangola P, Pant H C
出版信息
Biochem Biophys Res Commun. 1983 Feb 28;111(1):301-5. doi: 10.1016/s0006-291x(83)80151-x.
PMID:6830594
Abstract
Calcium bound calmodulin undergoes a reversible conformational change in the temperature range (22-28 degrees C). The transition temperature depends upon the concentration of calcium bound to calmodulin. The transition occurs at higher temperature (28 degrees C) in fully Ca2+ bound calmodulin as compared to those with lower Ca2+ concentrations (22 degrees C). The sequence of filling the four Ca2+ binding sites is different for the two temperature dependent conformers.
摘要
与钙结合的钙调蛋白在22至28摄氏度的温度范围内会发生可逆的构象变化。转变温度取决于与钙调蛋白结合的钙的浓度。与较低钙离子浓度（22摄氏度）的情况相比，在完全结合钙离子的钙调蛋白中，转变发生在更高的温度（28摄氏度）。对于两种温度依赖性构象体，填充四个钙离子结合位点的顺序是不同的。
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