Kryzhanovskiĭ G N, Ponomarchuk V S, Ruseev V V
Biull Eksp Biol Med. 1983 Jan;95(1):14-7.
Microinjection of tetanus toxin into the limbic system structures (hippocamp, subiculum, presubiculum, parasubiculum) or chronic electric stimulation of these structures resulted in the formation of the generator of pathologically enhanced excitation (GPEE), followed by disturbances in the intraocular pressure regulation (IOPR). The most pronounced alterations in the IOPR were recorded in forming the GPEE in the dorsal hippocamp. In the first stage the hippocampal theta-rhythm was suppressed, and then the spike and spike-wave potentials appeared. Normalization of the electric activity in the GPEE zone was followed by normalization of the intraocular pressure. The electric stimulation of the same zone of the dorsal hippocamp after normalization of the IOPR led to the reappearance of the disturbances in the ophthalmotonus regulation.
将破伤风毒素微量注射到边缘系统结构（海马体、下托、前下托、旁下托）或对这些结构进行慢性电刺激，会导致病理性增强兴奋发生器（GPEE）的形成，随后眼内压调节（IOPR）出现紊乱。在背侧海马体中形成GPEE时，记录到IOPR最明显的变化。在第一阶段，海马体θ节律受到抑制，随后出现棘波和棘慢波电位。GPEE区电活动正常化后，眼内压也恢复正常。IOPR正常化后，对背侧海马体同一区域进行电刺激，会导致眼内压调节紊乱再次出现。
